Fig. 11. Restoration of Hsp27 in cells containing A1038V ABCA4: (A) A1038V ABCA4 containing cells were transfected with Hsp27 and treated with VX-809. The data shows that increasing Hsp27 levels does not have an effect on A1038V. VX-809 does indeed cause a significant increase of approximately 2-fold in steady state levels. The combination of Hsp27 overexpression and addition of VX-809 are not synergistic. (B) Hsp27 transfection, with or without VX-809 (20 µM). Protein density was normalized to Ezrin. Data were represented as mean ± SEM (n=3-6). One way Anova was used for statistics. **P<0.01.